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Modeling the Functional Network for Spatial Navigation in the Human Brain
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The developing Human Connectome Project fetal functional MRI release: Methods and data structures.

Vyacheslav R Karolis1,2, Lucilio Cordero-Grande1,3, Anthony N Price1

  • 1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

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Summary
This summary is machine-generated.

This study releases the largest open-access fetal functional MRI dataset, enabling new research into early brain development and connectivity. The data addresses challenges like motion and noise, advancing the field of in utero neuroscience.

Keywords:
dynamic distortion correctionfetal fMRInetwork analysisopen-access data resourceslice-to-volume motion correctiontemporal filtering

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Medical Imaging

Background:

  • Fetal functional MRI (fMRI) offers insights into early brain development.
  • Progress is limited by a lack of accessible, high-quality fetal fMRI datasets.
  • Challenges include motion, geometric distortions, and low signal-to-noise ratio in utero.

Purpose of the Study:

  • To release the largest open-access fetal fMRI dataset to date.
  • To provide a resource for developing and benchmarking methods for in utero brain imaging analysis.
  • To facilitate research into the emergence of functional brain connectivity.

Main Methods:

  • Release of 275 fetal fMRI scans (255 fetuses, 20.86-38.29 weeks).
  • Systematic pre-processing including multi-band SENSE, distortion correction, slice-to-volume reconstruction, and temporal filtering.
  • Development of an advanced registration infrastructure for group-level analysis.

Main Results:

  • The largest open-access fetal fMRI dataset is now available.
  • A comprehensive pre-processing pipeline tailored for in utero data is presented.
  • The dataset includes intermediate processing outputs for flexible data exploration.

Conclusions:

  • This dataset release significantly advances the potential of fetal fMRI research.
  • It provides a crucial resource for developing robust analysis methods for early brain connectivity.
  • The findings support the development of a lifelong human connectome.