Related Experiment Video
Updated: Sep 11, 2025

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
Published on: June 6, 2025
HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2
Huiying Li1,2, Siying Cai1, Hongbei Mu1
1Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
None:
Diminished ovarian reserve (DOR) is a physiological or pathological condition that progresses in an age-dependent manner, which is characterized by impaired ovarian follicle quality, decreased anti-Müllerian hormone levels, elevated follicle-stimulating hormone levels, and reduced antral follicle counts. Oxidative stress (OS) is one of the culprits of DOR. By imposing OS damage on various kinds of ovarian cells including granulosa cells, OS can result in ovarian hypofunction and eventually lead to female infertility. However, the underlying mechanisms have not been fully elucidated yet. In this study, HIGD1A, a mitochondrial inner membrane component, is found to be downregulated in granulosa cells upon OS exposure. By systematically studying the role of HIGD1A in regulating granulosa cell and ovarian functions as well as its corresponding mechanisms, a novel regulatory mechanism underlying OS-related female infertility is revealed, and provided a potential molecular target for anti-OS therapies.
Related Concept Videos
Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Oogenesis
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...

