Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oogenesis02:07

Oogenesis

70.6K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
70.6K
Oogenesis01:22

Oogenesis

4.4K
Oogenesis,  the process of developing egg cells (female gametes), occurs within the ovaries and is fundamental to female fertility. This sequence begins during fetal development when diploid oogonia in the developing ovaries undergo mitotic divisions to produce primary oocytes. By birth, these primary oocytes enter prophase I of meiosis but become arrested in this stage, remaining suspended until puberty.
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is...
4.4K
Folliculogenesis01:20

Folliculogenesis

2.8K
Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
2.8K
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

7.2K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
7.2K
Nondisjunction01:21

Nondisjunction

5.3K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
5.3K
The Nucleolus02:55

The Nucleolus

10.5K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
10.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration.

Science (New York, N.Y.)·2026
Same author

A de novo C-terminal truncation mutation in NUP205 as a key factor in premature ovarian insufficiency.

Human reproduction (Oxford, England)·2026
Same author

Gene regulatory landscape dissected by single-cell four-omics sequencing.

Nature·2026
Same author

Dynamic regulation of astral microtubule growth in the meiotic spindle of mouse oocyte.

Reproduction (Cambridge, England)·2026
Same author

HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

The Brain Mechanisms of Music Stimulation, Motor Observation, and Motor Imagination in Virtual Reality Techniques: A Functional Near-Infrared Spectroscopy Study.

eNeuro·2025
Same journal

Periodontitis-Associated Circulating EVs Promote Colorectal Cancer Progression via Carnosine-Mediated Acidosis Adaptation.

Cell proliferation·2026
Same journal

PLIN5 Protects Against Ang II-Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet-Mitochondria Contact.

Cell proliferation·2026
Same journal

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap.

Cell proliferation·2026
Same journal

The E-cadherin-Wnt-mir-994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance.

Cell proliferation·2026
Same journal

A Multicellular Coordinated Network Driving Lymphovascular Space Invasion in Endometrioid Endometrial Carcinoma.

Cell proliferation·2026
Same journal

RETRACTION: Long Non-Coding RNA HCG11 Modulates Glioma Progression Through Cooperating With miR-496/CPEB3 Axis.

Cell proliferation·2026
See all related articles

Related Experiment Video

Updated: Feb 28, 2026

Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay
08:00

Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay

Published on: June 16, 2021

4.8K

BOLL-Containing Aggregates Mediate the Translational Regulation During Human Oogenesis.

Ying Li1, Lingya Mao1, Boyuan Liang1

  • 1The State Key Laboratory for Complex, Severe, and Rare Diseases; SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine; School of Basic Medical Sciences, Tsinghua Medicine, Tsinghua University, Beijing, China.

Cell Proliferation
|February 26, 2026
PubMed
Summary
This summary is machine-generated.

Human oocyte meiosis uses specialized RNA-binding proteins (RBPs) to control development. BOLL protein forms aggregates during meiosis, reprogramming translation and regulating cell cycle genes for reproductive success.

Keywords:
human BOLL proteinoogenesisprotein aggregatetranslational regulation

More Related Videos

Production and Use of Customizable Agarose Molds for Scaffold-Free Mouse Ovarian Follicle Culture
09:50

Production and Use of Customizable Agarose Molds for Scaffold-Free Mouse Ovarian Follicle Culture

Published on: October 24, 2025

705
Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes
12:11

Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes

Published on: May 11, 2017

11.5K

Related Experiment Videos

Last Updated: Feb 28, 2026

Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay
08:00

Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay

Published on: June 16, 2021

4.8K
Production and Use of Customizable Agarose Molds for Scaffold-Free Mouse Ovarian Follicle Culture
09:50

Production and Use of Customizable Agarose Molds for Scaffold-Free Mouse Ovarian Follicle Culture

Published on: October 24, 2025

705
Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes
12:11

Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes

Published on: May 11, 2017

11.5K

Area of Science:

  • Reproductive Biology
  • Molecular Cell Biology
  • Genetics

Background:

  • Human oocyte meiosis relies on post-transcriptional control of mRNA stores.
  • Germ cell-specific RNA-binding proteins (RBPs) regulate this process, but their mechanisms are unclear.

Purpose of the Study:

  • To investigate the role of BOLL, a DAZ family protein, in human oogenesis.
  • To elucidate the mechanism of RBP-mediated translational control during meiosis.

Main Methods:

  • Integrative translatome-transcriptome analysis.
  • RNA immunoprecipitation sequencing.
  • Semi-denaturing electrophoretic analysis (protein aggregates).
  • Human foetal ovarian tissues and hESC-derived oogenesis models.

Main Results:

  • BOLL forms SDS-resistant protein aggregates during meiotic prophase.
  • BOLL enhances translation efficiency of cell cycle regulators.
  • BOLL interacts with core translation machinery via its DAZ domain.
  • BOLL aggregates control cell cycle genes spatiotemporally during meiosis.

Conclusions:

  • BOLL-containing protein aggregates drive translational reprogramming in human oogenesis.
  • This represents an evolutionarily conserved mechanism for mammalian reproductive regulation.