Cytoskeleton-associated protein 4: a double-edged sword in cell growth and aging

Area of Science:

• Cell Biology
• Molecular Biology
• Gerontology

Background:

• Cytoskeleton-Associated Protein 4 (CKAP4) is a multifunctional protein involved in cellular processes.
• CKAP4 plays a role in cytoskeletal organization, signal transduction, and extracellular matrix remodeling.
• Emerging evidence suggests CKAP4 has a dual role in regulating cell growth and aging.

Purpose of the Study:

• To review the molecular mechanisms of CKAP4 in cell longevity and aging.
• To discuss CKAP4's involvement in inflammation and tissue homeostasis.
• To explore CKAP4 as a potential therapeutic target for age-related disorders.

Main Methods:

• Literature review of studies on CKAP4 function in cellular processes.
• Analysis of CKAP4's interactions with signaling pathways (e.g., PI3K/Akt) and ligands (e.g., APF, DKK1).
• Examination of CKAP4's role in extracellular matrix remodeling and inflammatory responses.

Main Results:

• CKAP4 promotes cell proliferation and survival via PI3K/Akt, delaying senescence physiologically.
• CKAP4 can induce cell cycle arrest and accelerate aging under chronic stress by interacting with APF and DKK1.
• CKAP4 links extracellular matrix remodeling to inflammation, relevant to age-related diseases.

Conclusions:

• CKAP4's function in aging is context-dependent, promoting longevity or accelerating aging.
• CKAP4 is a key mediator in inflammation and tissue homeostasis.
• CKAP4 presents a potential therapeutic target for aging-related diseases.