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Recent Advances in Isatin-Thiazole Hybrids: Synthesis, Structural Design, and Biological Application.

Isadora M G Andrade1, Edson de O Lima Filho1, Caio F Valadão1

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|August 13, 2025
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Summary

Isatin-thiazole hybrids are versatile scaffolds for drug discovery, offering diverse pharmacological properties. This review details their synthesis and biological activities, including anticancer and anti-inflammatory effects, for potential therapeutic applications.

Keywords:
heterocyclesindolemolecular hybridizationorganic synthesispharmacophoresmall molecules

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Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Pharmacology

Background:

  • Isatin-thiazole hybrids are recognized as privileged scaffolds in medicinal chemistry.
  • Their broad pharmacological spectrum makes them attractive for drug development.
  • Extensive research focuses on these hybrid heterocycles to discover potent new drugs.

Purpose of the Study:

  • To provide a comprehensive survey of synthetic strategies for isatin-thiazole derivatives.
  • To summarize the diverse biological activities of these compounds.
  • To offer an updated overview of their potential therapeutic applications based on studies up to 2024.

Main Methods:

  • Review of synthetic routes targeting the isatin core.
  • Compilation of reported biological activities.
  • Literature search up to 2024.

Main Results:

  • Detailed synthetic strategies for isatin-thiazole derivatives are presented.
  • Compounds exhibit promising anticancer, anticonvulsant, anti-HIV, anti-inflammatory, antidiabetic, and antioxidant properties.
  • Key reactive sites of the isatin core influencing synthesis are highlighted.

Conclusions:

  • Isatin-thiazole derivatives represent a significant class of compounds with broad therapeutic potential.
  • Understanding their synthesis and biological profiles is crucial for future drug discovery.
  • This review serves as a valuable resource for researchers in the field.