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Updated: Sep 11, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
New-onset diabetes mellitus post COVID-19 infection: a systematic review and meta-analysis
Emma Cocking1, Joseph Daher1, Majid Alabbood2
1School of Medicine, The University of Notre Dame Australia, Sydney, Australia.
Aims:
This systematic review and meta-analysis aimed to determine the relative risk of new-onset diabetes mellitus (NODM) in COVID-19 patients compared to individuals without COVID-19, with subgroup analyses based on diabetes type, age, severity of COVID-19 infection and corticosteroid use.
Methods:
PubMed, Medline, Embase, and Scopus were systematically searched for peer-reviewed cohort studies comparing NODM incidence in COVID-19 patients against a control group without COVID-19. A random-effects meta-analysis was conducted to determine the relative risk of NODM following COVID-19 infection.
Results:
A total of 12 studies were included, involving over 48 million participants. The risk of developing NODM was 41 % higher in patients following COVID-19 infection compared to the control group (RR 1.41; 95 % CI 1.07-1.84). Subgroup analysis revealed a higher incidence of type 2 compared to type 1 diabetes mellitus post COVID-19 infection, and increased risk of NODM in adults and patients with higher severity of disease.
Conclusion:
COVID-19 infection is associated with a significantly higher risk of NODM. Close monitoring for hyperglycaemia should be considered following COVID-19 infection, especially in adult patients requiring hospital or ICU admission.
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