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Updated: Jan 16, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
PROTOCOL: New-Onset Diabetes Mellitus Post COVID-19 Infection: A Protocol for Systematic Review and Meta-Analysis: A
Emma Cocking1, Joseph Daher1, Majid Alabbood1,2
1School of Medicine The University of Notre Dame Australia Sydney New South Wales Australia.
Background:
Emerging evidence suggests that coronavirus disease 2019 (COVID-19) infection may cause diabetes mellitus in patients without a prior history of the condition.
Objective:
This review aims to determine the incidence of new-onset diabetes mellitus in COVID-19 patients compared to individuals without COVID-19, including rates of diabetic ketoacidosis, hyperglycaemia, mortality, and intensive care unit admission. Subgroup analyses will investigate patients receiving corticosteroid therapy for COVID-19, patients admitted to hospital due to COVID-19, and the incidence of new-onset diabetes mellitus in relation to diabetes mellitus worldwide. The incidence of new-onset diabetes mellitus post-infection after a 6-12-month follow-up will also be reported.
Methods:
This protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines and is registered in PROSPERO (CRD42023457569). Eligible studies will include published and peer-reviewed cohort studies in English, after 1 December 2019. PubMed, Medline, Embase, and Scopus will be systematically searched. Included studies should compare new-onset diabetes mellitus incidence in COVID-19 patients against a control group without COVID-19. Two independent reviewers will extract data from included studies and assess risk of bias using the Newcastle-Ottawa quality assessment scale. A random-effects meta-analysis will compare the relative risk of new-onset diabetes mellitus post COVID-19 infection compared to non-infected individuals.
Conclusion:
The findings of this review will contribute to understanding the bidirectional relationship between COVID-19 and diabetes mellitus and inform clinical management strategies for patients at risk.
Systematic Review Registration:
PROSPERO CRD42023457569.
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