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Continuous Radiofrequency for Morton's Neuroma: Is There Complete Ablation? A Preliminary Report.

Gabriel Camuñas-Nieves1, Alejandro Fernández-Gibello1, Simone Moroni2

  • 1Clínica Vitruvio, C/María de Guzmán 47, 28003 Madrid, Spain.

Healthcare (Basel, Switzerland)
|August 14, 2025
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Summary

Continuous radiofrequency treatment for Morton's neuroma may not fully ablate nerves, potentially leading to pain recurrence. Histological analysis revealed intact nerve tissue, suggesting incomplete nerve destruction.

Keywords:
Morton’s neuromahistological analysisnerve ablationneuromaradiofrequency

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Area of Science:

  • Podiatry
  • Neurology
  • Surgical Techniques

Background:

  • Morton's neuroma causes foot pain, treatable with radiofrequency.
  • Radiofrequency treatment failure rates range from 15-20%.

Purpose of the Study:

  • To histologically assess the effects of continuous radiofrequency on nerves affected by Morton's neuroma.
  • To investigate potential causes of treatment failure in radiofrequency ablation for Morton's neuroma.

Main Methods:

  • Continuous radiofrequency applied ex vivo to surgically excised Morton's neuroma samples from two patients.
  • Standard protocol used: TLG10 RF generator (90°C, 90s) with a monopolar needle (0.5 cm active tip).
  • Histological analysis performed to evaluate the degree of nerve ablation.

Main Results:

  • Histological examination revealed homogeneous focal necrosis in both samples.
  • Lesion depths measured were 2.4 mm and 3.18 mm.
  • Intact nerve tissue identified at the periphery of the neuromas, indicating incomplete ablation.

Conclusions:

  • Continuous radiofrequency does not ensure complete nerve ablation for Morton's neuroma.
  • Incomplete nerve ablation may explain treatment recurrence and persistent pain.
  • Intraoperative neurophysiological monitoring could enhance procedural efficacy by ensuring full nerve conduction interruption.