Related Experiment Video
Updated: Sep 11, 2025
07:21
Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions
Published on: June 6, 2025
307
High-Fructose-Induced Salt-Sensitive Hypertension: The Potential Benefit of SGLT4 or SGLT5 Modulation.
Sharif Hasan Siddiqui1, Noreen F Rossi1,2
1Department of Physiology, Wayne State University, Detroit, MI 48201, USA.
Nutrients
|August 14, 2025
Summary
High salt and fructose intake worsen hypertension and cardiovascular disease. Targeting SGLT5 transporters may offer new strategies for managing salt-sensitive hypertension and related heart conditions.
Area of Science:
- Cardiovascular Science
- Nephrology
- Metabolic Disease
Background:
- Hypertension is a major cardiovascular disease risk factor.
- High salt and fructose intake exacerbate hypertension and cardiovascular issues.
- Fructose is absorbed by the small intestine and reabsorbed by kidney tubules via transporters like SGLT4 and SGLT5.
Purpose of the Study:
- To review the roles of SGLT4 and SGLT5 in fructose absorption, salt-sensitive hypertension, and cardiovascular disease.
- To explore the potential of targeting these transporters for therapeutic interventions.
Main Methods:
- Literature review of studies on SGLT4, SGLT5, fructose, salt-sensitive hypertension, and cardiovascular disease.
- Analysis of gene knockout studies in rats regarding fructose consumption and blood pressure.
Main Results:
- SGLT4 gene knockout does not affect fructose-induced blood pressure changes.
- SGLT5 knockout rats show no increase in blood pressure despite fructose consumption.
- SGLT5 mRNA is expressed in the heart, suggesting a direct role in cardiovascular function.
Conclusions:
- SGLT5 plays a significant role in mediating the hypertensive effects of fructose.
- Targeting SGLT5 offers a promising therapeutic avenue for salt-sensitive hypertension and cardiovascular disease.
- Developing fructose inhibitors that target SGLT transporters could mitigate adverse cardiovascular effects.
More Related Videos
09:29Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells
Published on: March 5, 2019
5.8K
08:08Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta
Published on: June 10, 2015
11.4K
Related Concept Videos
01:32Secondary Active Transport
7.6K
One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
7.6K
01:27Glucose Transporters
24.1K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
24.1K
01:28Antihypertensive Drugs: Potassium-Sparing Diuretics
768
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
768
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
508
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
508
01:30Heart Failure V: Medical Management
23
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
23
01:26Glucose Absorption Into the Small Intestine
32.4K
Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
32.4K