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Angiotensin II and Atherosclerosis: A New Cardiovascular Risk Factor Beyond Hypertension
Nicola Morat1, Giovanni Civieri1, Matteo Spezia2
1Cardiology Division, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.
International Journal of Molecular Sciences
|August 14, 2025
Summary
Angiotensin II (AngII) significantly contributes to cardiovascular disease beyond hypertension. This review explores its role in atherosclerosis development and progression, highlighting the renin-angiotensin-aldosterone system
Area of Science:
- Cardiovascular Science
- Endocrinology
- Pathophysiology
Background:
- Angiotensin II (AngII) is a key factor in cardiovascular disease, with established therapies targeting its inhibition.
- The AngII type 1 receptor mediates AngII's effects, driving hypertension, cardiac and vascular remodeling, and organ damage.
Purpose of the Study:
- To review the role of AngII and the renin-angiotensin-aldosterone system in cardiovascular risk.
- To explore the connection between AngII and atherosclerosis development and progression, extending beyond hypertension.
Main Methods:
- Literature review synthesizing existing research on AngII, the renin-angiotensin-aldosterone system, and cardiovascular disease.
- Focus on studies investigating AngII's impact on atherosclerosis.
Main Results:
- AngII activation of its type 1 receptor triggers cellular responses contributing to cardiovascular pathology.
- The renin-angiotensin-aldosterone system's influence on cardiovascular risk extends to atherosclerosis.
Conclusions:
- AngII plays a critical role in cardiovascular disease pathogenesis, including atherosclerosis.
- Understanding AngII's multifaceted actions is crucial for managing cardiovascular risk.
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