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Related Experiment Video

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Simultaneous Remote Non-Invasive Blood Glucose and Lactate Measurements by Mid-Infrared Passive Spectroscopic

Ruka Kobashi1, Daichi Anabuki1, Hibiki Yano1

  • 1Graduate School of Science for Creative Emergence, Kagawa University, 2217-20 Hayashi-cho, Takamatsu 761-0396, Kagawa, Japan.

Sensors (Basel, Switzerland)
|August 14, 2025
PubMed
Summary

This study introduces mid-infrared passive spectroscopy for non-invasive health monitoring. The novel method successfully measured blood glucose and lactate levels simultaneously without physical contact.

Keywords:
mid-infrared passive spectroscopynon-invasive glucose measurementnon-invasive lactate measurementsimultaneous non-invasive measurements

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Area of Science:

  • Biomedical Optics
  • Spectroscopy
  • Medical Imaging

Background:

  • Mid-infrared passive spectroscopic imaging is a novel non-invasive remote sensing method.
  • It measures naturally emitted thermal radiation in the mid-infrared region based on Planck's law.
  • This passive approach enables safe, long-term monitoring without external light sources.

Purpose of the Study:

  • To demonstrate simultaneous, non-invasive measurement of blood glucose and lactate levels.
  • To evaluate localized metabolic changes using spectral data analysis.
  • To showcase the feasibility of multi-component monitoring without physical contact or biological sampling.

Main Methods:

  • Utilized mid-infrared passive spectroscopy to measure naturally emitted thermal radiation.
  • Conducted simultaneous measurements of blood glucose and lactate over approximately 80 minutes.
  • Applied k-means clustering analysis to spectral data for spatial and temporal metabolic change evaluation.

Main Results:

  • Demonstrated temporal correlation between spectroscopic emittance data and conventional blood sensor values.
  • Successfully visualized time-dependent lactate responses with spatial resolution in the upper arm.
  • Confirmed the feasibility of non-invasive, multi-component monitoring.

Conclusions:

  • Mid-infrared passive spectroscopic imaging offers a promising non-invasive method for simultaneous glucose and lactate monitoring.
  • The technique facilitates continuous health monitoring, medical diagnostics, and sports medicine applications.
  • This technology supports the development of next-generation healthcare solutions.