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Biocompatible Natural Polymer-Based Amorphous Solid Dispersion System Improving Drug Physicochemical Properties,
Arif Budiman1, Helen Ivana2, Kelly Angeline Huang1
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Bandung 45363, Indonesia.
Polymers
|August 14, 2025
Summary
Natural polymers offer a sustainable solution for amorphous solid dispersions (ASDs), improving drug solubility and stability. These natural polymer-based ASDs (NP-ASDs) present a biocompatible alternative to synthetic carriers in drug development.
Area of Science:
- Pharmaceutical Science
- Materials Science
- Biotechnology
Background:
- Poor aqueous solubility is a major hurdle for drug candidates, often leading to late-stage development failures.
- Current amorphous solid dispersion (ASD) technologies predominantly use synthetic carriers like polyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose (HPMC).
- Synthetic carriers raise concerns regarding long-term biocompatibility, residual solvents, and environmental sustainability.
Purpose of the Study:
- To review the development and application of natural polymer-based amorphous solid dispersions (NP-ASDs).
- To elucidate the bonding mechanisms by which natural polymers enhance drug performance in ASDs.
- To highlight the potential of NP-ASDs as sustainable and biocompatible drug delivery systems.
Main Methods:
- Literature review on natural polymer applications in amorphous solid dispersions.
- Analysis of bonding mechanisms between natural polymers and active pharmaceutical ingredients (APIs).
- Evaluation of physical stability and dissolution enhancement of NP-ASDs.
Main Results:
- NP-ASDs demonstrate enhanced physical stability compared to traditional ASDs.
- Natural polymers significantly improve the dissolution rates of poorly soluble drugs.
- The structural characteristics of natural polymers are crucial for stabilizing the amorphous state and controlling drug release.
Conclusions:
- NP-ASDs represent a promising advancement in pharmaceutical technology.
- Natural polymers offer a sustainable and biocompatible alternative to synthetic carriers for ASD formulation.
- NP-ASDs have the potential to overcome solubility limitations and improve the efficacy of drug candidates.
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