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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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Translational Regulation01:29

Translational Regulation

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Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
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The Nucleolus02:55

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The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
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Related Experiment Video

Updated: Sep 11, 2025

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar
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Published on: May 30, 2025

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Noncoding RNAs in periodontitis: Progress and perspectives (Review).

Yuanyi Feng1, Xiaolan Guo2, Yumeng Yang1

  • 1Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China.

International Journal of Molecular Medicine
|August 14, 2025
PubMed
Summary

Noncoding ribonucleic acids (ncRNAs) play a key role in periodontitis, a common inflammatory disease causing tooth loss. Understanding ncRNA functions offers new diagnostic and therapeutic strategies for this widespread condition.

Keywords:
circular RNAlong noncoding RNAnoncoding RNAperiodontitistherapeutics

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Area of Science:

  • Oral Biology and Immunology
  • Molecular Biology
  • Genetics

Background:

  • Periodontitis is a prevalent chronic inflammatory disease leading to periodontal tissue destruction and adult tooth loss.
  • It is recognized as a risk factor for several systemic diseases.
  • Noncoding ribonucleic acids (ncRNAs) are crucial regulators of biological processes, and their dysregulation is implicated in periodontitis pathogenesis.

Purpose of the Study:

  • To summarize the multifaceted roles and mechanisms of ncRNAs in periodontitis.
  • To explore the clinical potential of ncRNAs as diagnostic markers and therapeutic targets.
  • To highlight emerging research directions in ncRNA studies related to periodontitis.

Main Methods:

  • Review of current literature on ncRNAs in periodontitis.
  • Analysis of ncRNA functions in immune inflammation, bone homeostasis, and cell proliferation.
  • Discussion of recent technological advancements impacting ncRNA research.

Main Results:

  • ncRNAs are integral to the pathogenesis of periodontitis, influencing key biological pathways.
  • Abnormal ncRNA expression is linked to disease development and progression.
  • ncRNAs demonstrate significant potential for clinical applications in periodontitis diagnosis and treatment.

Conclusions:

  • ncRNAs are critical players in periodontitis, affecting immune and bone biology.
  • ncRNAs represent promising biomarkers and therapeutic targets for periodontitis.
  • Advanced technologies are accelerating the discovery of novel ncRNA functions and applications in periodontitis research.