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Ischemic Stroke ll: Pathophysiology

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: May 5, 2026

Three-dimensional Confocal Analysis of Microglia/macrophage Markers of Polarization in Experimental Brain Injury

Three-dimensional Confocal Analysis of Microglia/macrophage Markers of Polarization in Experimental Brain Injury

Published on: September 4, 2013

Lipid metabolism, microglia, and stroke.

Lei Chen¹, Minmin Zhang¹, Wei Wei²

¹Department of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.

Neural Regeneration Research

|August 14, 2025

Summary

Microglia and lipids significantly impact brain immunity post-stroke. Understanding their interaction, influenced by diet and gut microbiome, offers new therapeutic targets for stroke treatment.

Keywords:

cerebral hemorrhage diet gut microbiome inflammation ischemic stroke lipid metabolism microglia regeneration therapeutic targets

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Last Updated: May 5, 2026

Three-dimensional Confocal Analysis of Microglia/macrophage Markers of Polarization in Experimental Brain Injury

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Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia

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Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

Area of Science:

Neuroscience
Immunology
Metabolism

Background:

Microglia are key immune cells in the brain, sensitive to injury and regulating immune responses post-stroke.
Lipids, including peripheral metabolism and lipid droplet biogenesis, critically control microglial functions like activation and inflammation.
The interplay between microglia and lipids is central to neuroinflammation following stroke.

Purpose of the Study:

To explore the roles of microglia and lipids in post-stroke immune regulation.
To discuss the implications of peripheral lipid metabolism and microglia-lipid interactions in stroke.
To highlight the influence of diet and gut microbiome on stroke risk and outcomes via the gut-brain axis.

Main Methods:

This review synthesizes current research on microglia-lipid interactions in the context of stroke.
It examines the impact of peripheral lipid metabolism and its regulation.
It analyzes the role of the gut-brain axis, diet, and microbiome in neuroinflammation and stroke.

Main Results:

Microglia activation and function are modulated by lipid metabolism and availability.
Peripheral lipid changes and lipid droplet accumulation affect microglial responses post-stroke.
Diet and gut microbiome composition influence neuroinflammation and stroke outcomes through the gut-brain axis.

Conclusions:

Targeting lipid metabolism and microglial pathways presents a promising therapeutic strategy for stroke.
Modulating the gut-brain axis, diet, and microbiome may offer novel approaches to stroke prevention and treatment.
A comprehensive understanding of microglia-lipid interactions is crucial for developing effective stroke therapies.