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Updated: May 5, 2026
Three-dimensional Confocal Analysis of Microglia/macrophage Markers of Polarization in Experimental Brain Injury
Published on: September 4, 2013
Lipid metabolism, microglia, and stroke
Lei Chen1, Minmin Zhang1, Wei Wei2
1Department of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Abstract:
Microglia, lipids, and their interaction are found to play important roles in post-stroke immunity. Microglia are sensitive to detect environment change in injured brain. Activated microglia undergo phenotypical remodeling and trigger complex signal cascades to regulate immune responses after stroke. Lipids including peripheral lipid metabolism and lipid droplet biogenesis are involved in the control of microglia functions, such as activation, phagocytosis, proliferation, and pro-inflammation. In this review, we explore new scope of microglia and lipids in immune regulation of stroke. Implication of peripheral lipid metabolism after stroke is mentioned and advances in microglia-lipid interaction are discussed. We give a special focus on how diet and gut microbiome influence neuroinflammation system via gut-brain axis, and how these processes associate with the risk and outcome of stroke. Moreover, we reviewed the therapeutic targets related to lipid metabolism and microglial modulation after stroke. These can provide a prospective strategy for more efficient and safer treatment for ischemic and hemorrhagic stroke.
Insights
Microglia and lipids significantly impact brain immunity post-stroke. Understanding their interaction, influenced by diet and gut microbiome, offers new therapeutic targets for stroke treatment.
Area of Science:
- Neuroscience
- Immunology
- Metabolism
Background:
- Microglia are key immune cells in the brain, sensitive to injury and regulating immune responses post-stroke.
- Lipids, including peripheral metabolism and lipid droplet biogenesis, critically control microglial functions like activation and inflammation.
- The interplay between microglia and lipids is central to neuroinflammation following stroke.
Purpose of the Study:
- To explore the roles of microglia and lipids in post-stroke immune regulation.
- To discuss the implications of peripheral lipid metabolism and microglia-lipid interactions in stroke.
- To highlight the influence of diet and gut microbiome on stroke risk and outcomes via the gut-brain axis.
Main Methods:
- This review synthesizes current research on microglia-lipid interactions in the context of stroke.
- It examines the impact of peripheral lipid metabolism and its regulation.
- It analyzes the role of the gut-brain axis, diet, and microbiome in neuroinflammation and stroke.
Main Results:
- Microglia activation and function are modulated by lipid metabolism and availability.
- Peripheral lipid changes and lipid droplet accumulation affect microglial responses post-stroke.
- Diet and gut microbiome composition influence neuroinflammation and stroke outcomes through the gut-brain axis.
Conclusions:
- Targeting lipid metabolism and microglial pathways presents a promising therapeutic strategy for stroke.
- Modulating the gut-brain axis, diet, and microbiome may offer novel approaches to stroke prevention and treatment.
- A comprehensive understanding of microglia-lipid interactions is crucial for developing effective stroke therapies.
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