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Updated: Apr 11, 2026

A Miniaturized Glycan Microarray Assay for Assessing Avidity and Specificity of Influenza A Virus Hemagglutinins

A Miniaturized Glycan Microarray Assay for Assessing Avidity and Specificity of Influenza A Virus Hemagglutinins

Published on: May 29, 2016

Automated Label-Free Assay for Viral Detection and Inhibitor Screening via Biomembrane-Functionalized Microelectrode

Zixuan Lu¹, Jeremy Treiber², Konstantinos Kallitsis¹

¹Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge, CB3 0AS, UK.

Advanced Materials (Deerfield Beach, Fla.)

|August 14, 2025

Summary

This summary is machine-generated.

This study introduces a novel biosensor using host-cell membranes and microelectrodes to detect SARS-CoV-2 fusion events early. This platform accelerates antiviral drug discovery and pathogen-host interaction studies.

Keywords:

PEDOT:PSS SARS‐CoV‐2 SLB microelectrode array microfluidics

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Last Updated: Apr 11, 2026

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Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

Area of Science:

Biotechnology
Virology
Biosensor Technology

Background:

Current virus assays often use indirect readouts, are labor-intensive, and lack sensitivity to early viral fusion events.
Existing methods detect later stages like cell lysis or death, missing crucial early infection dynamics.

Purpose of the Study:

To develop a sensitive platform for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) fusion events.
To create a high-throughput system for antiviral drug screening and studying pathogen-host interactions.

Main Methods:

Utilized host-cell-derived supported lipid bilayers (hcd-SLBs) integrated with organic microelectrode arrays (OMEAs).
Engineered hcd-SLBs with angiotensin-converting enzyme 2 (ACE2) receptors for viral binding and fusion detection.
Integrated microfluidics for automation and miniaturized OMEAs for high-throughput analysis.

Main Results:

Successfully detected SARS-CoV-2 pseudo particles (VPPs) through both early (fusion) and late pathways.
Demonstrated the platform's efficacy as a drug-screening tool by testing neutralizing antibodies.
Achieved high-throughput data generation and scalability through microfluidic integration.

Conclusions:

The developed hcd-SLB/OMEA platform offers a sensitive, high-throughput method for early viral fusion detection.
This system advances the study of virus-host interactions and accelerates the discovery of antiviral therapeutics.