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A multi-omic integrative approach combining m6A-epitranscriptomic, transcriptomic, and splicing alternative events

Hatim Boughanem1,2,3,4,5, Jesus Pilo1,2, Alejandro Rego1,2

  • 1Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Malaga 29010, Spain.

Genes & Diseases
|August 14, 2025
PubMed
Abstract

No abstract available in PubMed .

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Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...