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Updated: Sep 11, 2025
09:09
Design and Analysis of Temperature Preference Behavior and its Circadian Rhythm in Drosophila
Published on: January 13, 2014
8.2K
Mathematical modeling of temperature-induced circadian rhythms.
Lingjun Lu1, Yannuo Li1, Rene Schloss2
1Chemical and Biochemical Engineering Department, Rutgers University, Piscataway, NJ, United States.
Frontiers in Systems Biology
|August 14, 2025
Summary
Body temperature rhythms can synchronize peripheral cellular clocks, acting as a potent entrainer for circadian rhythms. This research models how temperature oscillations influence cellular synchronization, revealing adaptive responses to changing temperature schedules.
Area of Science:
- Chronobiology
- Mathematical Biology
- Cellular Physiology
Background:
- The suprachiasmatic nucleus (SCN) synchronizes peripheral circadian clocks via various signals.
- Temperature entrainment is a proposed mechanism for circadian rhythm maintenance in vitro.
- The role of body temperature as a systemic cue for peripheral clocks is understudied.
Purpose of the Study:
- To develop a mathematical model for peripheral clock entrainment to temperature rhythms.
- To investigate the impact of temperature oscillations on mammalian peripheral clocks.
- To explore the effects of amplitude, magnitude, and schedule transitions on temperature entrainment.
Main Methods:
- Developed a semi-mechanistic mathematical model.
- Incorporated a heat shock transcription factor-1 (HSF1) and heat shock response (HSR) pathway.
- Simulated entrainment of clock genes under varying temperature conditions.
Main Results:
- Peripheral cells synchronize to temperature rhythms, exhibiting coherent dynamics.
- Absence of temperature rhythmicity abolishes oscillations.
- Temperature rhythm amplitude and period significantly affect synchronization.
- Personalized strategies enable adaptive responses to temperature rhythms.
Conclusions:
- Temperature is a significant entrainer of circadian rhythms.
- In vitro systems with temperature modulation can model circadian rhythm adjustments.
- Understanding temperature entrainment is crucial for studying circadian disruption.
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