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Strength training and sarcopenia-a mandatory link: focus on MicroRNAs
Erika Cione1,2, Diana Marisol Abrego-Guandique3, Aldo Chiari4
1Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Cosenza, Italy.
Frontiers in Aging
|August 14, 2025
Summary
Sarcopenia, a loss of muscle mass and strength in older adults, affects 10-16% globally. Strength training is crucial, and microRNAs may offer early detection and new drug targets for this public health issue.
Area of Science:
- Gerontology and Molecular Biology
Background:
- Increased life expectancy leads to a higher prevalence of age-related diseases, including sarcopenia.
- Sarcopenia affects 10-16% of older adults worldwide, posing a significant public health challenge.
- Muscle mass and strength loss in individuals aged 65-70 is a growing concern.
Purpose of the Study:
- To review the importance of strength training in managing sarcopenia.
- To highlight the role of microRNAs in sarcopenia.
- To explore microRNAs as potential early biomarkers and therapeutic targets for sarcopenia.
Main Methods:
- Literature review focusing on sarcopenia, strength training, and microRNAs.
- Analysis of microRNA expression patterns in sarcopenia.
- Exploration of microRNAs' regulatory role in protein synthesis.
Main Results:
- Strength training is essential for managing sarcopenia.
- MicroRNAs, which regulate protein synthesis, are implicated in sarcopenia.
- Altered microRNA expression is observed in sarcopenia, similar to other diseases.
Conclusions:
- MicroRNA signatures could clarify sarcopenia's etiopathology.
- MicroRNAs show promise as early diagnostic biomarkers for sarcopenia.
- MicroRNAs may serve as a basis for developing novel sarcopenia therapeutics.
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