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Related Experiment Videos

Phosphate absorption at different intestinal sites in the developing lamb.

E Scharrer

    Quarterly Journal of Experimental Physiology (Cambridge, England)
    |October 1, 1985
    PubMed
    Summary

    Phosphate absorption in lambs is highest in the mid-jejunum, decreasing with age. Early in life, the colon also absorbs phosphate efficiently, but this diminishes over time.

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    Area of Science:

    • Gastroenterology
    • Animal Physiology
    • Nutritional Science

    Background:

    • Phosphate is crucial for lamb development, impacting bone health and metabolic processes.
    • Understanding intestinal phosphate absorption is key to optimizing nutrition in young ruminants.
    • Age-related changes in nutrient absorption influence dietary requirements.

    Purpose of the Study:

    • To investigate net phosphate absorption across various intestinal sites in lambs.
    • To determine how age and diet affect phosphate absorption velocity.
    • To identify specific intestinal regions responsible for maximal phosphate uptake.

    Main Methods:

    • Studied phosphate absorption in lambs aged 1 week, 3-4 weeks, and 10-13 weeks.
    • Utilized ligated intestinal segments to measure phosphate disappearance from a solution.
    • Compared absorption in milk-fed lambs versus those on a solid diet.

    Main Results:

    • Mid-jejunum demonstrated the highest phosphate absorption rate across all groups.
    • Proximal colon absorption was significant in 1-week-old lambs but minimal in older lambs.
    • Phosphate absorption generally decreased with age, except in the distal jejunum.
    • Diet type (milk vs. solid) did not significantly alter absorption rates in lambs of the same age.
    • Galactose and glucose inhibited mid-jejunum phosphate absorption in young lambs.

    Conclusions:

    • The mid-jejunum is the primary site for phosphate absorption in developing lambs.
    • Age-dependent changes significantly influence phosphate uptake capacity in the lamb intestine.
    • Dietary carbohydrates can modulate phosphate absorption in early life, suggesting complex regulatory mechanisms.

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