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Remimazolam for Procedural Sedation During Cardioversion
Mitchell Hughes1, Cameron Kramer1, Marco Corridore2
1Heritage College of Osteopathic Medicine - Dublin Campus, Dublin, Ohio and Ohio University, Athens, OH, USA.
Cardiology Research
|August 14, 2025
Summary
Remimazolam, a novel benzodiazepine, effectively sedated adult patients for cardioversion. This rapid-acting sedative provided amnesia without significant respiratory or hemodynamic adverse effects, indicating its potential for procedural sedation.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Remimazolam is a short-acting benzodiazepine with sedative, anxiolytic, and amnestic properties.
- It is rapidly metabolized by tissue esterases, leading to quick recovery of clinical effects.
- Previous studies show efficacy in general anesthesia and procedural sedation.
Purpose of the Study:
- To evaluate the efficacy and safety of remimazolam for sedation during cardioversion in adult patients.
Main Methods:
- Retrospective review of six adult patients undergoing cardioversion.
- Intravenous remimazolam as the primary sedative agent.
- Analysis of administered doses, adjunctive agents, and adverse events.
Main Results:
- Remimazolam was used as the primary sedative in all six patients.
- No significant respiratory or hemodynamic adverse effects were observed.
- All patients achieved adequate amnesia, with no recall of the procedure.
Conclusions:
- Remimazolam appears to be an effective and safe sedative for cardioversion in adult patients.
- A single 5 mg bolus dose provided adequate sedation and amnesia.
- It demonstrated minimal impact on hemodynamic and respiratory function.
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