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Quantifying ocular microaberration using a high-resolution Shack-Hartmann wavefront sensor.

Seung Pil Bang1, Praveen Kumar2, Geunyoung Yoon3

  • 1Department of Ophthalmology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea.

Biomedical Optics Express
|August 14, 2025
PubMed
Summary
This summary is machine-generated.

A new high-resolution Shack-Hartmann wavefront sensor (SHWFS) quantifies microaberrations. This study found that microaberrations increase with age, impacting ocular optical quality.

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Area of Science:

  • Ophthalmology
  • Optical Engineering
  • Biomedical Optics

Background:

  • Microaberrations, or high-spatial-frequency wavefront errors, can affect visual quality.
  • Quantifying these subtle aberrations is crucial for understanding ocular health and optical performance.

Purpose of the Study:

  • To develop and validate a high-resolution Shack-Hartmann wavefront sensor (SHWFS) for quantifying ocular microaberrations.
  • To investigate the relationship between age and microaberration levels in normal subjects.

Main Methods:

  • A novel SHWFS with 20 µm resolution, small lenslets, and a large CMOS sensor was designed with 5× pupil magnification.
  • Ocular wavefronts were reconstructed using modal and zonal methods; microaberrations were isolated by subtracting the modal from the zonal wavefront.
  • Root mean square (RMS) of the difference was calculated as a metric for microaberration-induced wavefront distortions.

Main Results:

  • The mean RMS values of microaberrations showed a significant increase with age, from 13.5 ± 1.1 nm in the 20s to 16.3 ± 1.5 nm in the 50s.
  • A strong positive correlation was found between age and microaberration levels (R² = 0.73; P < 0.001).
  • The high-resolution SHWFS successfully quantified microaberration-induced wavefront distortions.

Conclusions:

  • The developed high-resolution SHWFS is feasible for quantifying microaberrations.
  • An age-related increase in ocular microaberrations was confirmed.
  • This technique can enhance optical quality assessment and aid in diagnosing age-related ocular conditions.