Related Experiment Video
Updated: Sep 11, 2025

Preparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer
Published on: April 27, 2020
Engineering Proteinosomes with Cellular-Like Functionalities
Renzhuo Li1, Xiaoman Liu1, Xin Huang1
1State Key Laboratory of Advanced Inorganic Fibers and Composites, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China.
None:
Recent development of various types of functional microcompartmentalized ensembles that can imitate rudimentary aspects of living cells has attracted great attentions in a wide range of research communities. Proteinosome is one typical form of these biomimetic structures. Significant advances in their construction have indicated that by utilizing interfacial self-assembly, polymer-based membrane templating, and hybrid lipid-polymer systems can achieve tunable permeability, mechanical stability, and stimuli-responsive behaviors, which is detailedly elaborated in this review. Additionally, this review emphasizes their functionalization strategies that enable programable bioactivity and communication, as well as community aggregation structures to build prototissues exhibiting cellular-like behaviors. Innovations in stimuli-responsive materials and multicompartmentalized architectures further enhance spatiotemporal control over biochemical processes, while the convergence of polymer chemistry, synthetic biology, and nanotechnology continues to expand the functional scope of proteinosomes, positioning them as transformative tools for next-generation artificial cell models or biomimetic materials. Having covered these topics in depth, this review hopes to inspire additional investigation into the research methodologies related to proteinosomes, furthermore the artificial cells, as well as possible applications in targeted cancer therapy, gene therapy, and artificial organelles design.
More Related Videos
10:28The Encapsulation of Cell-free Transcription and Translation Machinery in Vesicles for the Construction of Cellular Mimics
Published on: October 21, 2013
10:01Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
Published on: April 8, 2020
Related Concept Videos
Protein Complexes with Interchangeable Parts
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
Mechanical Protein Functions
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Eukaryotic Compartmentalization
For example, lysosomes in the animal...
Mechanisms of Membrane Domain Formation
Another mechanism for membrane domain formation involves membrane proteins interacting with...
Protein Translocation Machinery on the ER Membrane
Sec61 protein conducting channel
In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the...