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Updated: Sep 11, 2025

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
How perceived causal networks can complement case conceptualization, diagnostic classification, and data-based
Felix Vogel1, Tessa F Blanken2, Julian Burger3
1Department of Child and Adolescent Psychotherapy, University of Hamburg.
Abstract:
The personalization of psychopathology through the use of personalized symptom networks appears to be a promising approach for gaining deeper insights into the development and maintenance of mental disorders. One way to create such networks is by using the perceived causal networks (PECAN) method. In this method, respondents are systematically asked to quantify how their symptoms are causally linked. Answers are then visualized, either for the individual or aggregated for a group, as a directed network. PECAN can represent causal relations irrespective of their timescales and requires no data-hungry estimations. The following guidelines are intended to assist clinicians and researchers in the creation of personalized networks using the PECAN method. These networks can facilitate case conceptualization and personalization of treatments for individual patients and the description of groups of patients, revealing recurring feedback loops and central symptoms. Additionally, recommendations are provided regarding the procedures to be employed in the selection of nodes, assessment of edges, and visualization of the data. Furthermore, the potential for evaluating the reliability, validity, and clinical usefulness, as well as strengths, limitations, and future challenges of PECAN, is discussed. We conclude with an overview of the challenges of PECAN and a research agenda that highlights opportunities to improve the still very young method and implement it in clinical research and practice. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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