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PREVALENCE, RISK FACTORS, AND OUTCOMES OF RHEGMATOGENOUS RETINAL DETACHMENTS REPAIR IN MARFAN SYNDROME

Ahmed A Nagshbandi1,2, Moustafa S Magliyah1, Abdulrahman F Algwaiz1

  • 1Vitreoretinal Division, King Khalid Eye Specialist Hospital, Riyadh, Saudi Arabia.

Retina (Philadelphia, Pa.)
|August 14, 2025
PubMed
Abstract

Insights

Patients with Marfan Syndrome face a 33.1% risk of rhegmatogenous retinal detachment (RRD). Factors like trauma, ocular surgery, aphakia, and longer axial length increase this risk, but surgical repair offers high reattachment rates.

Area of Science:

  • Ophthalmology
  • Genetics
  • Retinal Surgery

Background:

  • Marfan Syndrome is a genetic disorder affecting connective tissue.
  • Retinal detachment is a known complication, but its prevalence and risk factors in Marfan Syndrome require further elucidation.

Purpose of the Study:

  • To determine the prevalence of rhegmatogenous retinal detachment (RRD) in patients with Marfan Syndrome.
  • To identify risk factors associated with RRD development in this population.
  • To evaluate the outcomes of surgical management for RRD in Marfan Syndrome patients.

Main Methods:

  • Retrospective chart review of 82 patients diagnosed with Marfan Syndrome and RRD.
  • Data collection included lens status, prior ocular surgeries, intraoperative findings, and follow-up outcomes.
  • Analysis focused on identifying statistically significant risk factors and surgical success rates.

Main Results:

  • Rhegmatogenous retinal detachment (RRD) occurred in 33.1% of eyes (54 out of 163) in the study cohort.
  • Significant risk factors for RRD included prior trauma, previous ocular surgery, lensectomy without intraocular lens implantation, aphakia, lens subluxation, and increased axial length.
  • Successful primary reattachment was achieved in 69.2% of eyes, with secondary repairs achieving reattachment in the remaining cases.

Conclusions:

  • Eyes with Marfan Syndrome have a substantial lifetime risk (33.1%) of developing RRD.
  • Specific factors such as trauma, ocular surgeries, aphakia, and high axial length are strongly associated with an increased risk of RRD.
  • Surgical intervention for RRD in Marfan Syndrome patients can achieve high rates of successful retinal reattachment.
Keywords:
Marfan syndromelens subluxationmyopiaretinal detachmentscleral bucklevitrectomy

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