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Published on: August 25, 2023
Anion transport across lipid bilayers by a hydrogen bonding homo[2]catenane
Krzysztof M Bąk1, Olga Kisiel1, Debashis Mondal1
1Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Żwirki i Wigury 101, 02-089 Warsaw, Poland. mchmielewski@chem.uw.edu.pl.
Abstract:
We report the first example of transmembrane anion transport mediated by a hydrogen-bonding homo[2]catenane. The catenane outperforms its non-interlocked analogues in chloride transport, highlighting the advantages of interlocked architectures in ionophore design. The synthesis of this electroneutral [2]catenane was enabled by doubly charged sulfate (SO42-), acting as a powerful anionic template.
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