Toward precision interventions and metrics of inflammaging

Area of Science:

• Gerontology
• Immunology
• Biomedical Science

Background:

• Inflammaging is a chronic, low-grade systemic inflammation associated with aging and age-related diseases (ARDs).
• It represents a convergence point for multiple aging mechanisms.
• The heterogeneity of inflammaging is influenced by individual lifelong exposures.

Purpose of the Study:

• To discuss the heterogeneity of inflammaging.
• To explore methods for measuring inflammaging and its relationship with aging clocks.
• To consider interventions that may counteract inflammaging.

Main Methods:

• Review and synthesis of current research on inflammaging.
• Discussion of inflammatory clocks for quantifying inflammatory age.
• Exploration of potential interventions like nutrition, physical activity, and gerotherapies.

Main Results:

• Inflammaging arises from a unique combination of genetics, lifestyle, socioeconomic factors, and environmental exposures.
• Inflammatory clocks quantify inflammatory age and correlate strongly with ARD incidence.
• Aging clocks intersect with inflammaging, highlighting its central role in aging.

Conclusions:

• Deepening the understanding of individual inflammaging enhances personalized aging trajectory insights.
• Knowledge of personalized inflammaging can inform precision interventions for ARDs.
• Targeting inflammaging offers a promising avenue for promoting healthy aging.