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Fatigue

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...

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Self-Reported Fatigue Levels Predict Performance on Attention Measures in Multiple Sclerosis.

Deanna Eilenberger^1,2, Laura E Korthauer^1,2, Jonathan Cahill³

¹Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA.

Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists

|August 15, 2025

Summary

In multiple sclerosis (MS) patients, higher self-reported fatigue levels correlate with poorer attention performance. This study highlights fatigue as a key factor impacting cognition in MS.

Keywords:

Anxiety Cognitive performance Depression Medical burden Multiple sclerosis Physical symptoms

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Area of Science:

Neuropsychology
Clinical Neurology

Background:

Multiple Sclerosis (MS) is a chronic neurological disease impacting cognitive function.
Cognitive deficits and psychological comorbidities are common in MS patients.
Medical burden, including polypharmacy and fatigue, may influence cognitive performance.

Purpose of the Study:

To investigate the relationship between cognitive performance and medical burden in MS patients.
To examine associations between cognitive function, depression, anxiety, and fatigue.
To identify factors influencing cognitive performance in a cohort of MS patients.

Main Methods:

Retrospective analysis of data from 106 MS patients.
Comprehensive neuropsychological evaluation assessing attention, processing speed, executive function, memory, and more.
Self-report measures for depression, anxiety, and fatigue levels.

Main Results:

Positive correlations found between medication count and depression.
Higher fatigue scores were associated with increased depression and anxiety.
Fatigue significantly predicted lower attention scores, independent of age and education.

Conclusions:

Self-reported fatigue is linked to attention deficits in MS patients.
Fatigue, as a component of medical burden, impacts cognitive performance.
Further research is needed to explore interventions targeting fatigue to improve cognition in MS.