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Updated: Sep 11, 2025
Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
A mitochondria-targeted sequence-activated fluorescent probe responsive to H2O2 and viscosity for imaging and
Wen Zhang1, Yuting Sheng1, Min Zhang1
1College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institutes of Biomedical Sciences, Shandong Normal University, Jinan 250014, Shandong, People's Republic of China. Lip@sdnu.edu.cn.
Abstract:
A mitochondria-targeted fluorescent probe (HV) sequentially activated by H2O2 and viscosity was constructed. Probe HV exhibits high specificity and excellent biocompatibility. Due to the upregulation of mitochondrial H2O2 and viscosity in cancer cells, HV is capable of illuminating hepatocellular carcinoma. HV surpasses the limitations of single-marker detection of liver cancer and enables powerful imaging-guided hepatic cancer resections, improving the precision of liver diagnosis and treatment.
