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Updated: Sep 11, 2025
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
9.6K
p53 Modulates the Gut-Liver Axis via PI3K/AKT/Wnt Signaling Pathways in Type 2 Diabetes
Summary
p53 deficiency worsens glucose and insulin tolerance in mice by disrupting hepatic and intestinal functions. This impacts the gut microbiota and signaling pathways, highlighting p53
Area of Science:
- Metabolic diseases
- Molecular biology
- Gastroenterology
Background:
- p53 protein regulates metabolic processes in diseases like obesity and diabetes.
- The role of p53 in glucose-lipid metabolism via the enterohepatic axis is not fully understood.
- Type 2 diabetes mellitus (T2DM) involves complex metabolic dysregulation.
Purpose of the Study:
- To investigate the effects of p53 deficiency on glucose-lipid metabolism in type 2 diabetic mice.
- To elucidate the mechanisms by which p53 influences hepatic and intestinal functions in T2DM.
- To explore the relationship between p53, gut microbiota, and T2DM development.
Main Methods:
- Studied p53 deficiency in type 2 diabetic mouse models.
- Analyzed glucose tolerance, insulin tolerance, hepatic glucose metabolism, and intestinal functions.
- Assessed intestinal microbiota composition and expression of key proteins (β-catenin, c-Myc).
Main Results:
- p53 deficiency led to more severe glucose and insulin intolerance in T2DM mice.
- p53 influences hepatic glucose metabolism via the PI3K/AKT pathway.
- p53 deletion impaired intestinal digestion, absorption, and secretion, reduced microbiota diversity, and altered protein expression (β-catenin, c-Myc).
Conclusions:
- p53 plays a crucial role in regulating glucose-lipid metabolism and maintaining intestinal homeostasis.
- p53 affects insulin secretion via the PI3K/AKT pathway and gut microbiota via the Wnt signaling pathway.
- p53 modulation is a potential therapeutic target for T2DM.
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