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Updated: Sep 8, 2025

A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
[Considerations on hypoxia and altitude]
1Secretaría de Salud, Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Terapia Intensiva Posquirúrgica Cardiovascular. Ciudad de México, México.
Abstract:
Hypoxia associated with altitude is known as hypobaric hypoxia and it is related to the decrease in barometric pressure and inspired oxygen pressure; as they decrease, hypoxia increases. High altitude inhabitants acclimatise-adapt with morphological, physiological and genetic changes over generations. There are major differences between high altitude, moderate altitude and sea level. The characteristics of inhabitants of places with moderate altitude have been considered similar to those who live at sea level. However, hypobaric hypoxia is present and oxygenation is lower than at sea level, and it is still unknown what other changes may be caused by hypobaric hypoxia at this altitude.
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