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Published on: May 25, 2022
Successful Improvement of Cardiac Function in Late-Onset Dilated Cardiomyopathy Due to the SLC25A20 c.199-10T>G
Huan Thanh Nguyen1, Phong Hoang Ninh2
1Department of Geriatrics and Gerontology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; Department of Cardiology, Thong Nhat Hospital, Ho Chi Minh City, Vietnam.
Background:
Cardiomyopathy due to SLC25A20 mutations typically manifests in the neonatal period, characterized by rapid progression and high mortality.
Case Summary:
A 62-year-old man presented with late-onset dilated cardiomyopathy (DCM) associated with a heterozygous SLC25A20 c.199-10T>G mutation. Comprehensive evaluation, including biochemical testing, echocardiography, cardiac magnetic resonance imaging, and invasive coronary angiography, ruled out other potential etiologies. The patient received guideline-directed medical therapy in conjunction with cardiac resynchronization therapy, leading to significant clinical and functional improvement.
Discussion:
To our knowledge, this represents the oldest reported case of SLC25A20-related DCM. This case highlights the clinical presentation, multimodal imaging findings, and therapeutic response in late-onset SLC25A20-related cardiomyopathy.
Take-Home Messages:
Although rare, SLC25A20 mutations can contribute to late-onset DCM. Optimized heart failure management, including multimodal therapeutic strategies, may improve cardiac function in patients with SLC25A20-related DCM.
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