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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Related Experiment Video

Updated: Sep 11, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Lower diet quality accelerates DNA methylation-based age.

Botong Shen1, Nicole Noren Hooten1, Nicolle A Mode1

  • 1Laboratory of Epidemiology and Population Sciences, National Institute On Aging, National Institutes of Health, 251 Bayview Boulevard Suite 100 Room 4C-222, Baltimore, MD, 21224, USA.

Geroscience
|August 15, 2025
PubMed
Summary
This summary is machine-generated.

Lower dietary quality accelerates biological aging, as measured by DunedinPACE (Dunedin Pace of Aging Calculated from the Epigenome). This study links poor diet to faster epigenetic aging in diverse adults over five years.

Keywords:
DNA methylationDiet indexDiet qualityDietary scoreHealth disparitiesInflammationMinority healthRace

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Area of Science:

  • Epigenetics and Aging Research
  • Nutritional Epidemiology
  • Longitudinal Health Studies

Background:

  • Dunedin Pace of Aging Calculated from the Epigenome (DunedinPACE) is a DNA methylation biomarker linked to healthy lifespan.
  • Limited research exists on diet quality's impact on DunedinPACE among diverse populations, specifically African American and White adults.

Purpose of the Study:

  • To investigate the longitudinal relationship between diet quality and DunedinPACE in a cohort of African American and White adults.
  • To determine if dietary patterns influence epigenetic aging over a five-year period.

Main Methods:

  • Utilized longitudinal data from 421 adults (aged 30-64) balanced by race, sex, and poverty status.
  • Assessed diet quality using the Dietary Inflammatory Index (DII) and Healthy Eating Index-2010 (HEI) at two time points.
  • Employed linear mixed-effects models to analyze the association between DII, HEI, and DunedinPACE, adjusting for covariates.

Main Results:

  • A higher DII score (indicating a more pro-inflammatory diet) was significantly associated with a higher DunedinPACE score (faster aging).
  • A higher HEI score (indicating better diet quality) was significantly associated with a lower DunedinPACE score (slower aging).
  • These associations remained consistent over the five-year study period, with initial cohort data showing a pro-inflammatory dietary pattern and low diet quality.

Conclusions:

  • Lower dietary quality is independently associated with a faster pace of epigenetic aging (DunedinPACE).
  • Diet quality plays a significant role in epigenetic mechanisms related to healthy aging.
  • Findings highlight the importance of diet in modulating biological aging processes across diverse populations.