Advance in the extraction, characterization, bioactivities, and application prospects of konjac oligosaccharide: A comprehensive review
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Updated: May 13, 2026

Automated Modular High Throughput Exopolysaccharide Screening Platform Coupled with Highly Sensitive Carbohydrate Fingerprint Analysis
Published on: April 11, 2016
Xiaoyan Chang1, Yi Han2, Cuiping Yang3
1Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China; Jiangsu Vocational College of Medicine, Yancheng, China.
Abstract:
Konjac has garnered significant attention for its dual roles in medicinal and nutritional applications, with konjac oligosaccharide (KOS) emerging as a bioactive compound of particular interest. KOS exhibits a wide range of biological activities, including laxative, immunomodulatory, glucolipid metabolism regulatory, antioxidative, antifatigue, anti-inflammatory, osteogenic, and prebiotic effects. Despite advances in its extraction, purification, and characterization, a deeper understanding of its structural properties and mechanisms of action remains essential. This review systematically examines the extraction, separation, and purification techniques of KOS, alongside its physicochemical properties, biological activities, structure-activity relationships, and potential applications. Additionally, the toxicity and safety profile of KOS are critically evaluated. By integrating these aspects, this review provides theoretical and technical insights to support the development of KOS-based functional foods, highlighting its potential in the food and nutraceutical industries.
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