Advances in β-Cyclodextrin-Driven Self-Healing Materials: Molecular Design and Multifunctional Applications

Area of Science:

• Materials Science
• Supramolecular Chemistry
• Biomaterials Engineering

Background:

• Supramolecular self-healing (SH) materials autonomously repair damage, enhancing system longevity and performance.
• Host-guest (HG) interactions are key in designing SH materials, with cyclodextrins (CDs) being particularly effective due to biocompatibility and complexation abilities.

Purpose of the Study:

• This review focuses on the design and development of HG-based SH materials, emphasizing cyclodextrin-mediated systems.
• It explores recent advancements and applications of these materials in various fields.

Main Methods:

• The review synthesizes information on cyclodextrin-based supramolecular self-healing systems.
• It examines their integration into hydrogels, smart coatings, and sensors.
• Emerging strategies like 3D printing and shape memory functionalities are also discussed.

Main Results:

• β-cyclodextrin (βCD)-based SH hydrogels show significant progress in biomedical applications (drug delivery, wound healing, tissue engineering).
• Applications extend to smart coatings (anti-fogging, fresh-keeping, anti-corrosion) and sensors for environmental and physiological monitoring.
• 3D printing and shape memory functionalities expand design potential.

Conclusions:

• βCD-based SH materials offer promising solutions for diverse biomedical, industrial, and environmental applications.
• Challenges in scalability, environmental sensitivity, and balancing mechanical strength with healing efficiency require further research.
• Innovative fabrication and interdisciplinary collaboration are crucial for future development.