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Correction: Abdollahi et al. Bioactive Carboxymethyl Starch-Based Hydrogels Decorated with CuO Nanoparticles: Antioxidant and Antimicrobial Properties and Accelerated Wound Healing In Vivo. <i>Int. J. Mol. Sci.</i> 2021, <i>22</i>, 2531.

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Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

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Published on: May 2, 2025

Advances in ionic liquid-based antimicrobial wound healing platforms.

Mahin Abdollahi¹, Aysan Baharian¹, Masoumeh Mohamadhoseini¹

¹Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 451951159, Iran. nikfarjam@iasbs.ac.ir.

Journal of Materials Chemistry. B

|August 29, 2024

Summary

Ionic liquid-based polymers show promise as advanced wound dressings. These cationic polymers disrupt bacterial membranes, offering effective antimicrobial action for surgical wound healing.

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Area of Science:

Biomaterials Science
Polymer Chemistry
Infectious Disease Research

Background:

Wound infections pose significant challenges in surgical settings, necessitating novel antimicrobial strategies.
Current treatments often face issues with microbial resistance and host cell toxicity.

Purpose of the Study:

To review the application of ionic liquid-based polymers in advanced wound healing.
To explore their antimicrobial mechanisms and synthesis.

Main Methods:

Literature review focusing on cationic polymers with quaternary ammonium, imidazolium, guanidinium, pyridinium, triazolium, or phosphonium groups.
Analysis of their membrane disruption mechanisms and mammalian cell toxicity.

Main Results:

Ionic liquid-based polymers demonstrate potent bactericidal properties.
These polymers effectively disrupt bacterial membranes, preventing resistance and showing low mammalian cell toxicity.

Conclusions:

Ionic liquid-based polymers are highly promising for developing next-generation antimicrobial wound dressings.
Further research into these materials can advance surgical wound care and combat infections.