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Preferences for implementing pharmacogenomics in pediatric primary care: a discrete choice experiment
Benjamin Q Duong1, Nathan D Seligson2,3, Kelsey J Cook2,3
1Nemours Children's Health, Wilmington, DE, USA.
Pediatric Research
|August 16, 2025
Summary
Pediatric primary care providers prioritize engaging champions, education, and evidence access for pharmacogenomics (PGx) service implementation. Understanding these needs is crucial for integrating PGx into pediatric care.
Area of Science:
- Pharmacogenomics implementation science
- Pediatric primary care integration
- Healthcare delivery research
Background:
- Pharmacogenomics (PGx) services are underutilized in pediatric primary care compared to adult specialty settings.
- Limited research exists on primary care providers' perspectives regarding PGx implementation in pediatrics.
Purpose of the Study:
- To assess primary care providers' preferences for implementing pharmacogenomics (PGx) services in their pediatric practice.
- To identify key factors influencing the integration of PGx into pediatric primary care.
Main Methods:
- A discrete choice experiment utilizing best-worst scaling was employed.
- The study surveyed primary care providers within a multistate pediatric health system.
- The survey design was informed by the Consolidated Framework for Implementation Research (CFIR) domains.
Main Results:
- Evidence Strength and Quality, Patient Needs and Resources, and Access to Knowledge and Information were highly prioritized.
- Knowledge and Beliefs, and Engaging and Champions were also identified as critical implementation factors.
- Adaptability, Peer Pressure, and Culture and Tension for Change were deemed less important.
Conclusions:
- Primary care providers emphasized the need for practitioner champions and targeted education for successful PGx implementation.
- Establishing robust access to PGx evidence and resources for both providers and patients is essential.
- These findings provide a foundation for developing effective strategies to integrate PGx into pediatric primary care settings.
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