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A wearable and wireless electrochemical device based on Cu-BTC MOF for pyocyanin detection and wound healing
Jingwen Zhang1, Mei Wen1, Danqi Wang1
1Xiangya School of Public Health, Central South University, Changsha, Hunan, 410078, China.
Insights
This study developed a wearable device using a copper-based metal-organic framework (Cu-BTC) for sensitive pyocyanin (PYO) detection in infections. The device offers rapid, wireless wound monitoring and exhibits antimicrobial properties for enhanced healing.
Area of Science:
- Materials Science
- Biomedical Engineering
- Analytical Chemistry
Background:
- Antimicrobial resistance in Pseudomonas aeruginosa (PA) poses a global health threat.
- Pyocyanin (PYO) is a key virulence factor and indicator of PA infections.
Purpose of the Study:
- To develop sensitive signal amplifiers for pyocyanin detection.
- To create a wearable device for real-time electrochemical evaluation of pyocyanin in wounds.
Main Methods:
- Evaluation of ten metal-organic frameworks (MOFs) for pyocyanin reduction.
- Modification of electrodes with Cu-MOFs, specifically Cu-1,3,5-benzene tricarboxylic acid (Cu-BTC).
- Development of a wireless electrochemical wearable device for wound monitoring in rat models.
Main Results:
- Cu-MOFs, especially Cu-BTC, significantly enhanced pyocyanin reduction.
- The wearable device demonstrated high sensitivity (LOD 93.5 pM), stability, and selectivity.
- The device showed antimicrobial properties, aiding wound healing.
Conclusions:
- Cu-BTC is a superior signal amplifier for pyocyanin detection.
- The developed wearable device enables sensitive, wireless electrochemical monitoring of wound infections.
- The device's antimicrobial activity contributes to improved wound healing.
Abstract:
The prevalent and serious antimicrobial resistance in Pseudomonas aeruginosa (PA) infections has emerged as a critical public health challenge worldwide. Pyocyanin (PYO), an important virulence component produced by PA, is considered as an ideal indicator for identifying infections linked to this pathogen. This study evaluated ten metal-organic frameworks (MOFs) as signal amplifiers for the sensitive detection of PYO. The findings reveal that electrodes modified with Cu-MOFs exhibited a notable enhancement in current for PYO reduction. Particularly, Cu-1,3,5-benzene tricarboxylic acid (Cu-BTC) demonstrated superior enhancement for PYO reduction, primarily due to its smaller particle size and larger availability of active copper sites. Building on these findings, an innovative wearable device using Cu-BTC was developed to facilitate the wireless electrochemical evaluation of PYO in wounds artificially produced in Sprague-Dawley rat models. The findings indicate that this biocompatible device not only possesses exceptional sensitivity for detecting PYO with a limit of detection (LOD) of 93.5 pM with remarkable stability and selectivity but also shows antimicrobial properties that aid in the wound healing process.
