Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Leaky Scanning02:28

Leaky Scanning

5.2K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.2K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.3K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.3K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

4.1K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biofilm-derived curli and Z-DNA shape anti-DNA antibody responses during Salmonella infections.

PLoS pathogens·2026
Same author

Predictive models of adverse outcomes of overweight or obesity: a nationwide cohort validation.

BMC endocrine disorders·2026
Same author

Dirty mice better recapitulate key features of mRNA vaccine immunogenicity observed in humans.

mBio·2026
Same author

The Vertebrate Genomes Project Phase I: A global reference genome resource.

bioRxiv : the preprint server for biology·2026
Same author

Oncogenic KRAS-driven type I interferon signalling primes pancreatic cancer for necroptosis.

Nature communications·2026
Same author

Microbial Landscape of Bull (<i>Bos taurus</i>) Ejaculate: Assessment of Diversity and Link to Fertility.

Animals : an open access journal from MDPI·2026

Related Experiment Video

Updated: Sep 11, 2025

Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies
14:48

Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies

Published on: December 26, 2012

26.6K

Lung cell fates during influenza.

Brianna Jarboe1,2, Maria Shubina2, Ryan A Langlois3

  • 1Drexel University College of Medicine, Philadelphia, PA, USA.

Cell Research
|August 17, 2025
PubMed
Summary

Influenza A virus (IAV) infections cause significant global mortality. Understanding IAV-induced lung inflammation and host immune responses is crucial for developing new therapies against severe influenza.

More Related Videos

Imaging Cell Interaction in Tracheal Mucosa During Influenza Virus Infection Using Two-photon Intravital Microscopy
08:01

Imaging Cell Interaction in Tracheal Mucosa During Influenza Virus Infection Using Two-photon Intravital Microscopy

Published on: August 17, 2018

8.4K
Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
07:07

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

5.4K

Related Experiment Videos

Last Updated: Sep 11, 2025

Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies
14:48

Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies

Published on: December 26, 2012

26.6K
Imaging Cell Interaction in Tracheal Mucosa During Influenza Virus Infection Using Two-photon Intravital Microscopy
08:01

Imaging Cell Interaction in Tracheal Mucosa During Influenza Virus Infection Using Two-photon Intravital Microscopy

Published on: August 17, 2018

8.4K
Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
07:07

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

5.4K

Area of Science:

  • Virology and Immunology
  • Respiratory Medicine

Background:

  • Influenza A viruses (IAVs) infect approximately 1 billion people annually, causing severe respiratory illness and mortality.
  • Zoonotic spillover events, such as avian H5N1 in dairy cows, pose a significant threat, with potential for adaptation to human transmission.
  • Excessive host immune responses, particularly in lung tissues, contribute substantially to influenza-induced pathology, often independent of viral load.

Purpose of the Study:

  • To review recent advances in understanding IAV-host interactions within the lung.
  • To explore how IAV infection impacts cellular biology and contributes to lung pathology.
  • To identify therapeutic targets within virus-induced hyper-inflammatory pathways.

Main Methods:

  • This is a review article, synthesizing current research on IAV pathogenesis and host responses.
  • It examines cellular targets of IAV, consequences of infection on cell biology, and contributions to lung pathology.
  • It discusses therapeutic strategies focusing on modulating host-initiated inflammatory processes.

Main Results:

  • IAV infection triggers maladaptive immune responses that drive lung tissue damage and pathology.
  • Specific cell types targeted by IAV play a critical role in the development of influenza-associated lung disease.
  • Virus-induced hyper-inflammatory responses offer novel entry points for therapeutic intervention.

Conclusions:

  • A deeper understanding of IAV-induced lung inflammation and cellular responses is essential for effective treatment.
  • Targeting host-pathological processes, such as Z-form nucleic acid-binding protein 1 (ZBP1)-initiated necroptosis, shows therapeutic promise.
  • Developing anti-inflammatory strategies that modulate the host response could mitigate severe influenza outcomes.