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Probing the pH-Induced Spectral Modifications of NSAIDs for Designing Molecular Logic Gates and Combinational Logic
M N Ravikantha1,2, Vibha1, H M Suresh Kumar3
1Department of Physics, Vijayanagara Sri Krishnadevaraya University, Ballari, India.
Summary
This study demonstrates how acetaminophen and diclofenac
Area of Science:
- Analytical Chemistry
- Physical Chemistry
- Molecular Spectroscopy
Background:
- Non-steroidal anti-inflammatory drugs (NSAIDs) like acetaminophen and diclofenac exist in different ionic forms based on solution pH.
- These ionic variations significantly alter their absorption and fluorescence spectra.
Purpose of the Study:
- To investigate the pH-dependent spectral properties of acetaminophen and diclofenac.
- To explore the potential of these spectral changes for creating chemical-based logic gates and circuits.
Main Methods:
- Measurement of absorption and emission spectra of acetaminophen and diclofenac in aqueous solutions at various pH levels.
- Analysis of spectral shifts attributed to molecular protonation/deprotonation.
- Design and simulation of logic gate operations using spectroscopic outputs.
Main Results:
- Significant pH-dependent changes in absorption and fluorescence spectra were observed for both NSAIDs.
- These spectral behaviors were successfully utilized to implement unimolecular logic gates (IMP, INH, XNOR) using H+ and OH- as chemical inputs.
- The feasibility of designing digital logic circuits like magnitude comparators and half-subtractors was explored.
Conclusions:
- The pH-responsive spectral characteristics of acetaminophen and diclofenac can be harnessed for molecular logic operations.
- This research opens avenues for developing novel chemical sensors and information processing systems based on drug molecules.
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