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Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Mitral Stenosis III: Medical Management01:26

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Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Mitral Valve Prolapse II: Assessment and Management

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IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
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Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Related Experiment Video

Updated: Sep 11, 2025

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
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Microaxial Support as a Bridge to Repair in Post-Myocardial Infarction Ventricular Septal Rupture: A Systematic

Nayeem Nasher1, Daler Rahimov1, Keerti Mallur2

  • 1Department of Cardiac Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

Artificial Organs
|August 18, 2025
PubMed
Summary

Delayed surgical repair for post-infarct ventricular septal rupture (VSR) using microaxial support shows promising outcomes. This approach can successfully bridge unstable patients to surgery, reducing high mortality rates associated with immediate repair.

Keywords:
Impellabridge to repairmicroaxial supportventricular septal rupture

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Related Experiment Videos

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Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Mechanical Circulatory Support

Background:

  • Immediate surgical repair of post-infarct ventricular septal rupture (VSR) is recommended but associated with high mortality.
  • Delayed surgical management bridged with microaxial support offers an alternative approach.

Purpose of the Study:

  • To evaluate the outcomes of delayed surgical management for post-infarct VSR using microaxial support.
  • To assess the feasibility and safety of bridging hemodynamically unstable patients to surgery.

Main Methods:

  • A literature search identified 42 case reports/series with 78 patients diagnosed with post-infarct VSR and treated with microaxial support.
  • Patient-level data were extracted and analyzed based on survival status.

Main Results:

  • 76% of patients were successfully bridged to definitive surgical management.
  • The 30-day/in-hospital mortality rate was 22%, and overall mortality was 27%.
  • Survivors had a significantly higher Qp/Qs ratio and were less likely to have a history of prior cardiac surgery or prior percutaneous coronary intervention.

Conclusions:

  • Microaxial devices provide safe and feasible support for delayed repair in hemodynamically unstable post-infarct VSR patients.
  • This strategy can improve outcomes for selected patients.