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Updated: Sep 11, 2025

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
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NIR-Switched DNA Shutter Enables Reversible Intermittent cGAS-STING Activation for Enhanced Antitumor Immunity

Shiyi Bi1, Ruowen Yang1, Yulin Cong1

  • 1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Journal of the American Chemical Society
|August 18, 2025
PubMed
Summary

This study introduces an intermittent STING agonist for immunotherapy. This novel approach uses reversible activation to enhance immune response and tumor cell killing, overcoming resistance associated with continuous pathway stimulation.

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