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Disorders of gut-brain interaction in children: what is new

Darius Blanding1,2, Jaime Belkind-Gerson1,2, Alexandra Leigh Kilgore1,2

  • 1Digestive Health Institute, Children's Hospital Colorado.

Current Opinion in Pediatrics
|August 18, 2025
PubMed

Insights

New insights reveal prenatal SSRI exposure and childhood experiences as key risk factors for pediatric disorders of gut-brain interactions (DGBIs). Management requires a multimodal approach combining medications, behavioral therapies, and neuromodulation for improved outcomes.

Area of Science:

  • Pediatric Gastroenterology
  • Neurogastroenterology
  • Child Psychology

Background:

  • Pediatric disorders of gut-brain interactions (DGBIs) affect up to 30% of children.
  • Recent research has enhanced understanding of DGBIs' complex etiology and management.

Purpose of the Study:

  • To review and synthesize recent (post-late 2023) literature on pediatric DGBIs.
  • To cover predisposing factors, diagnostic tools, and therapeutic strategies.

Main Methods:

  • Comprehensive literature review of studies published since late 2023.
  • Synthesis of findings on risk factors, diagnostics, and treatments for pediatric DGBIs.

Main Results:

  • Identified in utero SSRI exposure and adverse childhood experiences as significant risk factors.
  • Highlighted the utility of gastric motility studies (e.g., dual-phase gastric emptying).
  • Detailed advancements in pharmacologic (e.g., linaclotide) and nonpharmacologic (e.g., CBT, PNFS) therapies.

Conclusions:

  • Pediatric DGBIs are multifactorial, with newly identified prenatal and psychosocial risk factors.
  • A multimodal treatment strategy integrating pharmacologic, behavioral, and neuromodulation is supported.
  • Further research and FDA approvals are needed to optimize pediatric DGBI management.
Abstract

Keywords:
childhood adverse eventsdisorders of gut–brain interactiongastric accommodationpercutaneous nerve field stimulation

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