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A functional abnormal antithrombin III (AT III) deficiency: AT III Charleville
Thrombosis Research
|September 1, 1985
Summary
A novel antithrombin III (AT III) defect, AT III Charleville, was identified in a patient with recurrent venous thrombosis. This defect causes reduced antithrombin activity, leading to unstable thrombin complexes.
Area of Science:
- Biochemistry
- Hematology
- Molecular Biology
Background:
- Recurrent venous thrombosis can be linked to inherited thrombophilias.
- Antithrombin III (AT III) is a crucial anticoagulant protein.
- Functional AT III defects can predispose individuals to thrombotic events.