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Decoding the impact of gut microbiota on heart failure
Shuhong Zhao1,2, Lingxuan Dan1,2, Rong Huang1,2
1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Genes & Diseases
|August 18, 2025
Summary
Heart failure impairs the gut, altering gut microbiota composition. Modulating this gut dysbiosis shows promise for managing heart failure and its risk factors.
Area of Science:
- Cardiology
- Gastroenterology
- Microbiology
Background:
- Reduced cardiac output in heart failure causes intestinal ischemia and increased gut permeability.
- Heart failure is associated with significant gut microbiota alterations, including decreased beneficial and increased harmful bacteria.
Purpose of the Study:
- To review the role of gut microbiota in heart failure pathogenesis.
- To highlight therapeutic strategies targeting gut dysbiosis for heart failure management.
Main Methods:
- Literature review of studies investigating the gut microbiota in heart failure.
- Analysis of the relationship between gut microbiota, risk factors, and heart failure progression.
Main Results:
- Gut dysbiosis is linked to heart failure risk factors like hypertension, diabetes, obesity, and renal insufficiency.
- Microbiota-derived metabolites contribute to heart failure progression via bloodstream dissemination.
Conclusions:
- Gut microbiota plays a significant role in the development and progression of heart failure.
- Targeting gut dysbiosis through interventions like probiotics or fecal microbiota transplantation offers a promising therapeutic avenue for heart failure.
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