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Related Experiment Video

Updated: Sep 11, 2025

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders

Published on: May 31, 2024

Arterial Spin Labelling Perfusion Changes in Persistent Migrainous Aura Without Infarction.

Bhadra Sajeev Nair^1,2, Vandana Sudheer³, Boby Varkey Maramattom²

¹Medicine, Malankara Orthodox Syrian Church Medical College Hospital, Kolenchery, Ernakulam, IND.

|August 18, 2025

Summary

This summary is machine-generated.

Persistent migraine aura symptoms lasting over a week can be non-invasively assessed using Arterial Spin Labelling (ASL) MRI. This technique detects reversible cerebral blood flow changes, distinguishing migraine aura from ischemic events.

Keywords:

arterial spin labelling (asl)cortical spreading depolarization migraine disorder scintillating scotoma visual aura

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Published on: June 2, 2023

Area of Science:

Neurology
Neuroimaging
Medical Diagnostics

Background:

Migraine is a prevalent neurological disorder causing recurrent headaches, often with aura symptoms like visual disturbances.
Migrainous aura without infarction describes prolonged aura symptoms without evidence of brain damage on imaging.
Arterial Spin Labelling (ASL) is a non-invasive MRI technique for quantifying cerebral blood flow.

Observation:

This case report focuses on persistent migrainous aura symptoms exceeding one week.
The study utilized ASL MRI to monitor cerebral perfusion changes during the migraine cycle.
ASL imaging revealed reversible perfusion abnormalities associated with the persistent aura.

Findings:

Arterial Spin Labelling (ASL) effectively detected reversible perfusion changes in persistent migrainous aura.
These perfusion changes aided in differentiating migrainous aura from ischemic stroke.
The findings suggest ASL can provide insights into migraine pathophysiology, potentially related to cortical spreading depression.

Implications:

ASL MRI offers a valuable non-invasive tool for diagnosing and managing persistent migrainous aura.
This technique can help clinicians distinguish migraine aura from more serious conditions like infarction.
Understanding perfusion dynamics through ASL may lead to improved therapeutic strategies for migraine.