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Invasive Gastric Candidiasis With Concurrent Clostridioides difficile Colitis: A Case Report and Review of the
Sevag Hamamah1, Garrett Teskey1, Wesley Chow1
1Internal Medicine, Scripps Mercy Hospital, San Diego, USA.
Cureus
|August 18, 2025
Summary
Invasive gastric candidiasis, a rare stomach infection, can cause bleeding ulcers, especially in elderly patients. This case highlights the importance of considering fungal infections in atypical gastric ulcers.
Area of Science:
- Gastroenterology
- Mycology
- Infectious Diseases
Background:
- Invasive gastric candidiasis is a rare fungal infection of the stomach, often associated with immunosuppression, critical illness, and disruption of the gut barrier.
- Candida species are normal gastrointestinal flora, but compromised host defenses can lead to overgrowth and tissue invasion.
Observation:
- A case report of an 89-year-old male presenting with upper gastrointestinal bleeding from diffuse gastric ulcers due to invasive gastric candidiasis.
- The patient also experienced diarrhea attributed to Clostridioides difficile colitis, indicating a potential interaction between these infections.
Findings:
- The case illustrates the complex interplay between antibiotic use, gut barrier dysfunction, microbial interactions, and escalating infections in an elderly individual.
- Invasive gastric candidiasis was identified as the cause of gastric ulcers and bleeding.
Implications:
- This case underscores the need for a high index of suspicion for fungal infections in elderly patients with atypical gastric ulcers, even without overt immunosuppression.
- Understanding the interactions between gastrointestinal candidiasis and Clostridioides difficile infection is crucial for effective management.
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