Related Experiment Video
Updated: Sep 11, 2025
09:43
Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis
Published on: December 16, 2013
18.9K
Synthesis, Characterization, and Potential Applications of New Silica-Phosphonium Nanoparticles
Matan Nissim1,2, Sivan Shoshani1,3, Gila Jacobi1,3
1The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 5290002, Israel.
ACS Omega
|August 18, 2025
Summary
New silane-phosphonium nanoparticles show promise as antibiofilm and antiviral agents, effectively inhibiting various pathogens and viruses like ToBRFV. These nanoparticles offer potential agricultural, environmental, and medical applications despite mammalian cell toxicity.
Area of Science:
- Materials Science
- Nanotechnology
- Biotechnology
Background:
- Antibiotics face challenges of toxicity and increasing bacterial resistance.
- Developing novel antibacterial and antiviral agents is crucial for health and industry.
- Silane-phosphonium compounds show potential as antimicrobial and antibiofilm agents.
Purpose of the Study:
- To synthesize and characterize novel poly-(silane-phosphonium) nanoparticles (NPs).
- To evaluate the antibiofilm and antiviral efficacy of these NPs.
- To explore potential applications in agriculture, environment, and medicine.
Main Methods:
- Modified Stöber polymerization process for NP synthesis.
- Characterization using scanning electron microscopy (SEM), dynamic light scattering (DLS), zeta potential, X-ray photoelectron spectroscopy (XPS), and Fourier-transform infrared (FTIR) spectroscopy.
- In vitro testing for inhibition of specific bacteria and viruses, including tomato brown rugose fruit virus (ToBRFV).
Main Results:
- Successfully synthesized and characterized poly-(silane-phosphonium) nanoparticles.
- Demonstrated significant potential in inhibiting bacterial growth and viral activity, including ToBRFV.
- NPs exhibited toxicity to mammalian cells, indicating a need for careful application.
Conclusions:
- Poly-(silane-phosphonium) nanoparticles are effective antibiofilm and antiviral agents.
- These NPs hold potential for diverse applications in agriculture, environmental protection, and medicine.
- Further research is needed to optimize NP formulations and assess in vivo safety and efficacy.
