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Stimuli-Responsive Oligolysine-PEG Coatings for Reductive-Triggered Decomplexation.

Hugo J Rodríguez-Franco¹, Artem Kononenko¹, Maartje M C Bastings¹

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Summary

This summary is machine-generated.

Responsive DNA origami nanoparticles (DONs) were developed using cleavable oligolysine-PEG coatings. These coatings protect DONs in physiological conditions and release them in the cell

Keywords:

DNA origami nanoparticles biointerfaces reductive deprotection stabilizing coatings stimuli-responsive polymers

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Area of Science:

Biotechnology
Nanotechnology
Materials Science

Background:

DNA origami nanoparticles (DONs) show promise for biological applications but face challenges from nuclease activity and ionic conditions.
Oligolysine-PEG coatings stabilize DONs but are static, limiting dynamic interactions and functional cue availability.

Purpose of the Study:

To develop responsive oligolysine-PEG coatings for DNA origami nanoparticles (DONs).
To enable controlled release and functional recovery of DONs in specific cellular environments.

Main Methods:

Incorporation of labile disulfide bridges into oligolysine segments of PEG coatings.
Synthesis and characterization of oligolysine-PEG variants with varying peptide segmentation.
Evaluation of DON protection under physiological conditions and decomplexation in reductive environments.

Main Results:

Developed oligolysine-PEG coatings that protect DONs in physiological conditions.
Demonstrated efficient decomplexation of DONs in reductive cellular environments via disulfide bond cleavage.
Observed that the number and positioning of disulfide linkers influence DON functional recovery.

Conclusions:

Responsive oligolysine-PEG coatings can be designed for stabilized DONs.
This strategy enhances the biomedical applicability of DONs by enabling controlled release and functionalization.
Provides a foundation for advanced responsive nanomaterials in biological systems.