Biomaterial-mediated Cell Atlas: an insight from single-cell and spatial transcriptomics.

Area of Science:

• Biomaterials science
• Cell biology
• Genomics

Background:

• Biomaterials interface with biological systems, but cell-material interaction mechanisms remain unclear.
• Understanding these interactions is crucial for developing effective biomaterials.

Purpose of the Study:

• Introduce the 'Biomaterial-mediated Cell Atlas' concept.
• Summarize advances in using transcriptomics for biomaterials research.
• Highlight transcriptomics for mapping cell-material communication.

Main Methods:

• Single-cell transcriptomics to analyze cellular diversity.
• Spatial transcriptomics to understand cellular arrangements.
• Transcriptomics-driven approaches for pathway mapping.

Main Results:

• Single-cell and spatial transcriptomics reveal cellular diversity and spatial effects on material interactions.
• Transcriptomics enables mapping of biomaterial-cell communication pathways.
• These methods are key to understanding biological mechanisms and guiding biomaterial design.

Conclusions:

• The Biomaterial-mediated Cell Atlas, powered by transcriptomics, offers a framework for studying biomaterial-cell interactions.
• Advanced transcriptomic technologies are essential for elucidating complex biological responses to biomaterials.
• This interdisciplinary field faces challenges but holds significant promise for future biomaterial innovation.