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Dynamic Dysregulation of Ribosomal Protein Genes in Mouse Brain Stress Models.

Vandana Sharma1,2, Rammohan Shukla1,2

  • 1Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA.

Stresses
|August 18, 2025
PubMed
Summary

Ribosomal protein genes (RPGs) show varied expression in mouse brain stress models, with downregulation more common. This conserved stress response highlights RPGs

Keywords:
evolutionheterogeneityribosomesstresssynapse

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Area of Science:

  • Neurobiology
  • Molecular Biology
  • Genetics

Background:

  • Ribosomal protein genes (RPGs) play a conserved role in stress adaptation across species.
  • The stress-induced RPG response is not well-characterized in mouse models of neurobiological stress.

Purpose of the Study:

  • To investigate ribosomal protein gene dysregulation patterns in diverse murine stress paradigms.
  • To identify non-canonical ribosomal functions using synaptic gene ontology terms in mouse brain regions.

Main Methods:

  • Analysis of available transcriptomic data from various murine preclinical stress paradigms.
  • Gene ontology enrichment analysis focusing on synaptic terms.

Main Results:

  • Observed heterogeneous dysregulation (up/downregulation) of cytoplasmic and mitochondrial RPGs across brain regions.
  • Downregulation of RPGs was more prominent than upregulation.
  • Dysregulation was more prevalent in chronic stress paradigms compared to acute or early-life stress.

Conclusions:

  • Ribosomal dysregulation is an evolutionarily conserved stress response in mouse models.
  • Dysregulated RPGs are significantly associated with post-synaptic gene ontology terms, indicating synaptic modulation roles.
  • Variability in dysregulation directionality may serve as a marker for neuronal activity in response to stress.